Spinal meningeal arachnoid cyst is a differential diagnosis as a cause of severe back pain with neurological symptoms. Noninfectious causes of meningitis noninfectious causeagent example a reference. Bacterial and fungal etiologies of meningeal irritation. We retrospectively analyzed three patients who underwent surgery for a suspected meningioma for whom the final diagnosis was. The frequency of the associated meningeal syndrome is a function of tumor type and of the proximity of tumor necrosis to the ventricles. Overview of the diagnosis and management of brain, spine. The presence of meningeal symptoms may not always indicate meningitis or subarachnoid al hemorrhage.
The patient had a fever of unknown origin, severe headache, progressing left ophthalmoplegia, and visual acuity disturbance. Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes poems syndrome is a rare plasma cell disease. Meningeal leukemia a syndrome resulting from increased intracranial pressure in patients with acute leukemia. Altered flow of cerebrospinal fluid csf within the subarachnoid space sas is connected to brain, but also optic nerve degenerative diseases. The uveo meningeal syndromes are a group of disorders that share involvement of the uvea, retina, and meninges. Clinical presentation, diagnosis, and radiological findings of.
That investigation was based on four cases, and all the characteristics of this tumor were not included. Major outbreaks of this condition have been documented in the meningitis belt of subsaharan africa. Brain tumors rarely may produce acute sterile meningitis the meningeal syndrome resulting from the spillage of blood, lipid products of tumor necrosis, or malignant cells into the cerebrospinal fluid csf. Meningeal syndrome may be caused by blood, cancer cells, or substances from the breakdown of cancer cells that get into the cerebrospinal fluid csf. Although much remains to be investigated, these new discoveries have changed our understanding of mechanisms underlying cns immune privilege and cns drainage.
Radicular irritation resulting in muscle spasms meningeal. Anatomically unspectacular disease may cause the clinical syndrome of cord compression by compromising the anterior spinal artery, resulting in infarction of the cord. For treatment of the aseptic meningitis, antiinflammatory drugs are a logical choice. Spinal meningeal cyst in a child with marfan syndrome. The development of urinary retention in the context of meningitis and csf pleocytosis without any lumbosacral radiculomyelitis is known as meningitis retention syndrome mrs. The anterior and posterior meningeal branches of the. Cranial pachymeningitis has occasionally been reported, but no histopathological studies have been performed. An infrequent cause of low back pain, only recently described, is the presence of a meningeal cyst within the lumbar or sacral canal. The posterior branch has been described previously 3, 4, 7. Conclusions inflammatory or autoimmune diseases are probably the most common clinically. We describe three unusual cases of meningeal rosaidorfman disease and illustrate the difficulties of preoperative and pathological diagnosis. Treponema pallidum, a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the body and can infect all its systems if not treated appropriately. Mr imaging revealed diffuse and thick hypointense lesions on t2weighted images in the frontal meninges and anterior falx cerebri with diffuse.
It arises from the vertebral artery above the level of the arch of the atlas just below the foramen magnum. It proved beneficial to prevent paradoxical reactions in tuberculous meningitis and in other described cases of cryptococcal meningitis associated iris. Download fulltext pdf two cases of uveomeningeal syndrome article pdf available in journal of the korean ophthalmological society 603. Among patients with any type of solid tumors, the highest incidence of meningeal carcinomatosis has been reported in patients with breast cancer 1234% and lung cancer 1026%, while the occurrence of meningeal. Meningeal definition of meningeal by medical dictionary. The patient had hyperpigmented skin lesions for 2 years and she had undergone enucleation of odontogenic keratocyst of anterior mandible 1 year earlier figure 1a. To overcome the lack of suitable in vitro models that faithfully recapitulate the intricate threedimensional architecture, complex cellular interactions, and fluid dynamics within the sas, we have developed a perfusion bioreactorbased 3d in.
The observation that cerebrospinal fluid csf pleocytosis is almost always associated with the clinical. Cerebrospinal fluid analysis in infectious diseases of the. Meningeal hemorrhage an overview sciencedirect topics. The polymerase chain reaction is a rapid and accurate method for detection of microbial. Meningitis is an acute inflammation of the protective membranes covering the brain and spinal. Meningeal syphilis as known as syphilitic aseptic meningitis or meningeal neurosyphilis is a chronic form of syphilis infection that affects the central nervous system. We describe the case of a 54yearold woman with a clinical diagnosis of churgstrauss syndrome css. Impaired meningeal lymphatic vessel development worsens. The aim of this prospective study was to contribute to the management of medical emergencies. Definition of meningeal syndrome nci dictionary of.
The payee may view, download, andor print the article for hisher personal, scholarly. On the other hand, the combination of acute urinary retention, herpetic genital vesicles, lumbosacral radicular pain, hypoesthesia and muscle weakness, was described over 75 years ago and is referred to as. Future studies should explore the communications between the glymphatic system and meningeal lymphatics in cns disorders and develop new therapeutic modalities targeting these systems. Meningeal calcification in basal cell nevus syndrome bmj. The first treatment in acute meningitis consists of promptly giving antibiotics and sometimes antiviral drugs. Peripheral neuropathy is the main neurological feature. Shortterm corticosteroid administration was shown to be safe and well tolerated in patients who are receiving antiretroviral treatment. The uveomeningeal syndromes are a group of disorders that share involvement of the uvea, retina, and meninges. Spinal and meningeal metastatic disease cancer imaging. Ten to 50% of patients with systemic malignancy develop brain metastases during the course of their disease and metastases account for more than half of all brain tumours in adults. Takahiro nagashima, kazuo muroi, masae kunitama, tohru izumi, tetsuya ohtsuki, norio komatsu, masashi fukayama, keiya ozawa, colon cancer with meningeal carcinomatosis and myelodysplastic syndrome in a patient who underwent intensive chemotherapy for acute myelogenous leukemia.
For more information on how to use laverne, please read the how to guide. Physical examination revealed no evidence of oral or genital ulcers. A 20yearold woman presented with history of headache for 1 year. Meningeal syndrome in the diseases of the internal organs. Meningeal carcinomatosis is characterized by diffuse invasion of tumor cells in the leptomeninges and cerebrospinal fluid, which occurs in 38% of all cancer patients. The headaches were mild to moderate in intensity, bilateral and nonthrobbing, with no symptoms suggestive of raised intracranial pressure. Meningeal syndrom signs and symptoms intracranial hypertension signs headache, nausea, vomitus. Meningeal irritation syndrome denotes to a range symptoms that require emergency management. How to differentiate the causes of meningeal syndrome.
Jeanpierre barral, alain croibier, in manual therapy for the cranial nerves, 2009. Since that communication was published five other patients with a tumor in the same location and manifesting additional signs. Spinal extradural meningeal cyst with spinal stenosis. Meningeal definition of meningeal by the free dictionary. The inflammatory process affects receptors and vessels soft meninges. Meningeal sign definition of meningeal sign by medical. Neoplastic meningitis is an event in the course of cancer with a variable. Sometimes meningeal syndrome is observed in acute pancreatitis, uremia, diabetes, hepatic encephalopathy, cerebral hypertensive crises, in exogenous intoxications, in flu, sore throat.
Improve your interpretation of presenting symptoms with 38 new topics and 40 new images in the differential diagnosis section, and optimize patient care with more than 250 new figures and tables. A perfusion bioreactorbased 3d model of the subarachnoid. The syndrome of meningeal leukemia is one of the major complications of acute leukemia. A condition marked by headache, fever, and a stiff neck, which is caused when the meninges three thin layers of tissue that cover and protect the brain and spinal cord become irritated. Meningeal chondroma in a young female article pdf available in indian journal of pathology and microbiology 531. Jci understanding the functions and relationships of the. Cooccurrence of multiple cerebral infarctions due to. The meningeal and choroidal infiltration routes for leukocytes in stroke. Once the level falls at about 3 months, incidence of meningitis increases, from 23 yrs. Download fulltext pdf two cases of uveo meningeal syndrome article pdf available in journal of the korean ophthalmological society 603. Epidemiological surveillance of meningeal and encephalic.
Cerebrospinal fluid cytology examination is a common and reliable primary andor complementary procedure for the diagnosis of central nervous system cns disorders. In a series of 11 patients with intracranial hypotension syndrome, brain magnetic resonance scans were evaluated for the thickness, distribution, morphology, and pattern of meningeal enhancement coincident with subdural fluid collections and the descent of. Meningeal metastatic disease in the cancer patient, epidural cord compression by bony metastasis is the commonest myelopathic presentation. Raven in 1912 attributed the nonnes syndrome to a certain clinical condition, namely to the lumbosacral spinal cord tumor but frequently tuberculous meningitis and meningeal carcinomatosis can be the under. Ocular involvement is a common clinical manifestation and often the presenting clinical feature. Clinically, it is an expression of an irritation of the meninges combining with headache, fever, neck stiffness, altered consciousness and vomiting. In the pathogenesis of meningeal syndrome is set to a number of factors. This is followed by development of meningeal syndrome with 2 to 3 weeks. In a previous study 1 was described a definite clinical picture noted in patients with a meningeal fibroblastoma arising from the lesser wing of the sphenoid bone. Meningeal bcell follicles in secondary progressive. Meningeal syndrome groups together symptoms connected with any pathological irritation of the meningeal envelopes and the cerebrospinal fluid.
Leptomeningeal carcinomatosis occurs in about 5% of cancer patients. All three syndromes meningeal, toxemic and intracranial hypertension. The major originating primary tumours are carcinomas typically arising from sites shown in fig 1. It accompanies biological changes in these components of the nervous system. Intracranial meningeal involvement in churgstrauss syndrome. We report a complication from caudal epidural block for anesthesia in a 4. Mri was obtained by t1w before and after gadolinium contrast materiel injection, thin. Vascular endothelial growth factor vegf seems to play a pathogenic role. The uveomeningeal syndromes request pdf researchgate. Focal neurologic signs consist of unior bilateral cranial nerve palsies vi iii, iv and viii. Background the uveo meningeal syndromes are a group of disorders that share involvement of the uvea, retina, and meninges. Although spinal extradural cysts causing cord compression were reported in the literature as far back as 1898 4, no reference to meningeal cysts in the sacral and lumbar regions appeared prior to 1951. Rosaidorfman disease of the central nervous system is extremely rare and difficult to diagnose also for pathologists. The murine meningeal lymphatic network begins to develop just before birth and is fully developed by postnatal day 28.
Both anterior and posterior meningeal branches of the vertebral artery arise from its extracranial segment to supply a portion of the dura of the posterior fossa. Cerebrospinal fluid cytology in nonmalignant aseptic. Cerebrospinal fluid formation about 70% of the csf present in the brain and spinal cord is produced by the choroid plexuses. Glioblastoma multiforme and the meningeal syndrome neurology. In the diagnosis of meningeal syndrome possibly bacterial meningitis due to an unknown germ versus decapitated and gbs, adalimumab was suspended and intravenous treatment with ceftriaxone. L robinson, r dominguez, j cabrera, j w yeakley, m j fenstermacher and m e milner american journal of neuroradiology. Return of meningeal symptoms in a patient treated for. Magnetic resonance imaging of intracranial hypotension. Meningeal rosaidorfman disease mimicking meningioma. Since the incidence is rare, diagnosis of spinal meningeal cysts often. Meningeal disorder bioinformatics tool laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on cocitations.